Therapeutics: Glycinamide ribonucleotide formyltransferase (GARFT); folate receptor 1 (FOLR1; FR-α); FOLR2 (FR-β); solute carrier family 46 folate transporter m

Mouse and cell studies identified an inhibitor of GARFT, FOLR1, FOLR2 and SLC46A1 that could help treat folate receptor-expressing cancers. Chemical synthesis and in vitro testing of pyrimidine antifo...