12:00 AM
 | 
Jul 30, 2015
 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Kruppel-like factor 4 (KLF4; EZF); galectin-3 (LGALS3)

Cardiovascular disease

INDICATION: Atherosclerosis

Cell culture and mouse studies suggest inhibiting KLF4 could help treat atherosclerosis. In atherosclerotic plaques, phenotypic conversion of smooth muscle cells to macrophage-like LGALS3-positive cells increases inflammation and reduces fibrous cap area, which promotes...

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