BioCentury
ARTICLE | Distillery Therapeutics

Therapeutics: Phosphoribosyl pyrophosphate synthetase 1 (PRPS1)

June 11, 2015 7:00 AM UTC

In vitro studies suggest the purine synthesis inhibitor lometrexol could help treat thiopurine-resistant ALL. In ALL cells from 358 patients who relapsed after thiopurine therapy, whole-genome sequenc...