BioCentury
ARTICLE | Distillery Therapeutics

Therapeutics: Hypoxia-inducible factor 1α (HIF1A; HIF1-α)

May 14, 2015 7:00 AM UTC

Cell culture and mouse studies suggest stabilizing HIF1A could help prevent or treat UTIs caused by uropathogenic Escherichia coli (UPEC). In UPEC-infected human uroepithelial cells, the HIF1A stabilizer AKB-4924 decreased bacterial counts and cell death compared with vehicle. In a mouse model of UPEC-associated UTI, pretreatment with transurethral AKB-4924 decreased pro-inflammatory cytokine production in the bladder and decreased bacterial loads in the urine, bladder and kidneys. In a mouse model of established UPEC-associated UTI, transurethral AKB-4924 decreased bacterial load in the bladder. Next steps could include developing oral formulations AKB-4924...