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May 07, 2015
 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Glucokinase (GCK; GK); glucokinase regulator (GCKR; GKRP)

Endocrine/metabolic disease

INDICATION: Diabetes

In vitro and rat studies suggest a thiazole sulfone-based disruptor of the GCK-GCKR complex could help treat Type II diabetes. Chemical synthesis and in vitro testing of aryl sulfone analogs identified a lead thiazole sulfone that inhibited GCK-GCKR binding with an IC50 of 6...

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