BioCentury
ARTICLE | Distillery Therapeutics

Therapeutics: Inositol polyphosphate-5-phosphatase D (INPP5D); spleen tyrosine kinase (SYK)

April 9, 2015 7:00 AM UTC

In vitro and mouse studies suggest hyperactivating SYK could help treat tyrosine kinase inhibitor (TKI)-resistant ALL. Philadelphia chromosome-positive (Ph+) ALL cells from patients expressed higher l...