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12:00 AM
Mar 12, 2015
 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Core-binding factor β subunit (CBFB; CBF-β); myosin heavy chain 11 smooth muscle (MYH11; SMMHC); runt-related transcription factor 1 (RUNX1)


INDICATION: Acute myelogenous leukemia (AML)

In vitro, mouse and patient sample studies suggest a small molecule protein-protein inhibitor could help treat the inv(16) subtype of AML. The subtype is driven by an oncogenic CBFB-SMMHC fusion protein that inhibits normal CBFB binding...

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