BioCentury
ARTICLE | Distillery Therapeutics

Therapeutics: Interferon-stimulated gene 15 (ISG15); ubiquitin specific peptidase 18 (USP18; ISG43)

March 5, 2015 8:00 AM UTC

Mouse studies suggest inhibiting the protease activity of USP18 could help treat viral infections. USP18 downregulates ISG15, which plays a role in interferon (IFN)-mediated responses to viral infecti...