BioCentury
ARTICLE | Distillery Therapeutics

Therapeutics: Phosphoinositide 3-kinase (PI3K) catalytic subunit β polypeptide (PIK3CB; p110-β); PI3K catalytic subunit α polypeptide (PIK3CA; p110α); phosphati

January 22, 2015 8:00 AM UTC

Cell culture and mouse studies suggest inhibiting PIK3CB could circumvent resistance to PIK3CA inhibitors in cancer. In a panel of human breast cancer cell lines sensitive to PIK3CA inhibitors, develo...