1:12 PM
 | 
Aug 01, 2018
 |  BC Innovations  |  Distillery Techniques

Assays and screens

TECHNOLOGY: Cell-free assays; high throughput screening

A high throughput, mass spectrometry-based screening assay could identify E3 ligase inhibitors and interactive pairs of E2/E3 ubiquitination enzymes as potential drug targets. For the latter, the method involves combining a single ubiquitin E1 activating enzyme with pairs of E2 and E3 enzymes in a 1,536-well plate and adding ubiquitin...

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