2:45 PM
 | 
Jul 10, 2018
 |  BC Innovations  |  Distillery Techniques

Drug delivery

TECHNOLOGY: Nanoparticles

Gold-based nanoparticles could be used to deliver CRISPR-Cas9 and CRISPR-Cas12a constructs for neurological diseases. The nanoparticles are generated by conjugating gold nanoparticles to DNA oligonucleotides that bind to the CRISPR endonuclease and single-guide RNA (sgRNA) complex, then encapsulating the particles with polymers that trigger endocytosis. In yellow fluorescent protein (YFP)-expressing...

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