BioCentury
ARTICLE | Distillery Techniques

Disease models

May 23, 2018 4:20 PM UTC

Mice treated prenatally with AMH could be used to screen therapies to treat polycystic ovary syndrome, a partially heritable disease. In blood samples from 66 pregnant patients with PCOS, AMH levels were higher than in samples from 63 age-matched, pregnant healthy volunteers. Offspring from pregnant mouse dams treated with AMH recapitulated the high serum levels of testosterone and luteinizing hormone, sporadic ovulation and fertility defects observed in PCOS patients. In the model mice, the GnRH/LHRH antagonist Cetrotide cetrorelix decreased testosterone and luteinizing hormone levels in the blood and estrus cycle defects, and increased the number of completed estrus cycles and numbers of corpora lutea and antral follicles in the ovary compared with vehicle. Next steps could include using the model to screen other PCOS therapies...