2:13 PM
 | 
Apr 17, 2018
 |  BC Innovations  |  Distillery Techniques

Disease models; drug properties

TECHNOLOGY: 3-D models; pharmacokinetics/pharmacodynamics

3-D human intestinal organoids could be used to test the PK properties of drug compounds. The organoids are generated by culturing human induced pluripotent stem (iPS) cells in a medium containing fibroblast growth factor 4 (FGF4) and a glycogen synthase kinase 3 (GSK3) inhibitor; seeding the cells in commercially available low-adherence scaffolds; suspending them in culture containing...

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