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Jun 18, 2015
 |  BC Innovations  |  Distillery Techniques

Techniques: Crystal structure of myeloid leukemia cell differentiation protein (MCL1)

Drug platforms

TECHNOLOGY: Crystal structures

Crystallographic studies on an MCL1 fusion protein could aid the structure-based design of MCL1-specific inhibitors. A fusion of maltose binding protein and MCL1 containing three mutations to enhance its crystal packing properties formed crystals on its own, and formed co-crystals with known MCL1 ligands, whereas unfused, wild-type MCL1 did not...

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