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2:45 PM, Jul 10, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Nanoparticles Gold-based nanoparticles could be used to deliver CRISPR-Cas9 and CRISPR-Cas12a constructs for neurological diseases. The nanoparticles are generated by conjugating gold nanoparticles to DNA oligonucleotides that bind to the CRISPR endonuclease and single-guide...
2:45 PM, Jul 10, 2018  |  BC Innovations | Distillery Techniques

Imaging

TECHNOLOGY: Other DESI-MS-based imaging could detect microscopic tumors in patient skin samples obtained during skin cancer surgery. The method involves three steps: using a beam of charged dimethylformamide/acetonitrile solvent to ionize molecules on the surface of...
2:44 PM, Jul 10, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Other An encapsulated, ionic solvent-based formulation of insulin could enable longer-lasting treatment of Type I diabetes than injected insulin. The formulation consists oral, enterically coated capsules containing insulin dispersed in a deep eutectic solvent (cationic/anionic...
2:44 PM, Jul 10, 2018  |  BC Innovations | Distillery Techniques

Biomarkers; other

TECHNOLOGY: Tissue markers; metabolomics; plasma markers; computational models Computational models based on profiles of the fecal metagenome, plasma and urine metabolites and the liver transcriptome could help diagnose hepatic steatosis in non-diabetic obese women. In 158...
10:47 AM, Jun 28, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Conjugates Hafnium (Hf)-based metal-organic complexes could enhance the sensitivity of solid tumors to radiotherapy. The complexes consist of nanoscale frameworks of six or 12 Hf atoms coordinated to molecules of 2,5-di(p-benzoato)aniline (DBA), in which the...
10:47 AM, Jun 28, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs SNPs on 124 genomic loci could help predict the risk of myopia and other ocular refractive errors. Genome-wide association studies (GWAS) in 255,925 individuals identified associations between ocular refractive errors including myopia and...
10:46 AM, Jun 28, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: Gene profiling; tissue markers A gene signature in tissue-resident memory T cells could help predict survival in TNBC. Single-cell RNA sequencing of more than 6,000 T cells from the tumor samples of two patients identified...
10:46 AM, Jun 28, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: 3-D models Patient-derived metastatic neuroendocrine prostate cancer organoids could be used to screen therapies for personalized medicine applications. The organoids are generated by culturing enzyme-dissociated cells from samples of a patient’s liver, lymph node and...
10:46 AM, Jun 28, 2018  |  BC Innovations | Distillery Techniques

Assays and screens; chemistry; drug platforms

TECHNOLOGY: Binding assays; tool compounds; antibody scaffolds A method for generating and screening synthetic nanobodies could be used to identify compounds that bind membrane proteins in a conformation-specific manner, for use as therapeutics or research tools....
10:46 AM, Jun 28, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Cell therapy CAR T cells with six ITAMS could have greater activity towards cancer cells than CAR T cells with the standard three ITAMS. The cells are generated by duplicating the CD3ζ (CD3z; CD247)...

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