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4:57 PM, Feb 13, 2018  |  BC Innovations | Distillery Techniques

Assays and screens

TECHNOLOGY: Cellular assays; high throughput screening A high throughput yeast-based method of antibody screening could help identify therapeutic antibodies in human blood. The method involves three steps: engineering a yeast strain with cell-surface expression of a...
8:59 AM, Feb 13, 2018  |  BC Innovations | Distillery Techniques

Assays and screens

TECHNOLOGY: Binding assays A method for unbiased detection of protein-small molecule interactions could be used to identify the protein targets of small molecules. The method involves four steps: exposing a proteome sample to a metabolite or...
8:58 AM, Feb 13, 2018  |  BC Innovations | Distillery Techniques

Other

TECHNOLOGY: Computational models A method for designing small molecules that covalently bind conserved catalytic lysines could be used to generate selective, irreversible kinase inhibitors. The method utilizes in silico modeling of the interactions between analogs of...
8:58 AM, Feb 13, 2018  |  BC Innovations | Distillery Techniques

Chemistry

TECHNOLOGY: Tool compounds A diazepine-based compound could be used to probe the role of SPPL2A in antigen-presenting cells (APCs) that drive rheumatoid arthritis, multiple sclerosis and other autoimmune diseases. Chemical synthesis, in vitro testing and cell-based...
8:58 AM, Feb 13, 2018  |  BC Innovations | Distillery Techniques

Assays and screens; disease models

TECHNOLOGY: Cellular assays; 3-D models A 3-D culture system that mimics brain tissue could be used to model drug resistance in glioblastoma multiforme and screen therapies. The system involves culturing human GBM cell lines in a...
8:57 AM, Feb 13, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs A SNP on PAD4 could help predict the risk of ALS. Genome-wide association studies in 1,955 ALS patients and 28,244 unaffected individuals identified an associations between a SNP on PAD4, SNP (rs2240335), and ALS,...
8:29 AM, Feb 07, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs; plasma markers Loss-of-function mutations in SLC7A8 could help predict the risk of age-related hearing loss. Whole-genome sequencing in blood samples from 66 age-related hearing loss patients and 81 healthy, elderly volunteers identified four loss-of-function...
8:29 AM, Feb 07, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Nanoparticles Polyamine-based nanoparticles loaded with AGO2 could be used as delivery vehicles for therapeutic siRNA. The nanoparticles consist of a polyamine capsule containing a therapeutic siRNA and AGO2, an RNA-induced silencing complex (RISC)-interacting protein that...
8:29 AM, Feb 07, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Cell therapy CAR T cells engineered to contain a JAK-STAT signaling domain could enhance proliferation and persistence of T cell therapies for cancer. The engineered CAR T cells consisted of standard CD19-targeting CARs engineered with...
8:28 AM, Feb 07, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Gene therapy Engineered, chimeric DNA-RNA guide nucleic acids could be used for CRISPR-based gene editing with fewer off-target effects than standard guide RNAs (gRNAs). The chimeric guides consist of standard gRNAs that have 10 RNA...

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