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9:20 AM, May 23, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: Tissue markers Tumor clone frequencies of TCRB in lesional skin could help predict survival and progression in mycosis fungoides, a subtype of cutaneous T cell lymphoma (CTCL). TCRB tumor clone frequency is calculated by sequencing...
9:20 AM, May 23, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: Animal models Mice treated prenatally with AMH could be used to screen therapies to treat polycystic ovary syndrome, a partially heritable disease. In blood samples from 66 pregnant patients with PCOS, AMH levels were higher...
9:20 AM, May 23, 2018  |  BC Innovations | Distillery Techniques

Assays and screens; biomarkers

TECHNOLOGY: Cell-free assays; gene profiling A method for profiling miRNAs in extracellular vesicles could be used to identify diagnostic markers for pancreatic and other cancers. The method involves linking magnetic anti-biotin microbeads to biotinylated antibodies that...
9:19 AM, May 23, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: Plasma markers Plasma levels of unmethylated RFLNA cfDNA could help diagnose MI or sepsis. In 70 patients with acute MI and 201 patients with sepsis, levels of unmethylated RFLNA cfDNA were higher than in 83...
9:19 AM, May 23, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Structural analyses Structural analyses of NPY1R bound to tool compound antagonists or its endogenous agonist NPY could guide the design of compounds that antagonize or agonize the receptor for obesity, cancer or bone loss....
11:32 AM, May 15, 2018  |  BC Innovations | Distillery Techniques

Assays and screens

TECHNOLOGY: Binding assays; cellular assays A click chemistry-based method for identifying cell surface glycoproteins that bind orphan ligands could help identify new therapeutic targets. The method involves three steps: mildly oxidizing live cells to produce aldehyde...
11:29 AM, May 15, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Targeting domains Tannic acid conjugates of therapeutic proteins or viral particles could be used for cardiac-specific delivery of therapies for myocardial infarction (MI) and other heart diseases. The method involves conjugating therapeutic proteins or viral...
11:29 AM, May 15, 2018  |  BC Innovations | Distillery Techniques

Assays and screens; imaging

TECHNOLOGY: Diagnostic assays; other An ultrasound-based assay for detecting blood flow in the pancreas could help predict disease progression and monitor treatment responses in Type I diabetes. The method involves injection of a gas-filled lipid microbubble...
11:29 AM, May 15, 2018  |  BC Innovations | Distillery Techniques

Biomarkers; other

TECHNOLOGY: Gene profiling; computational models A gene profiling-based computational model could identify single-gene deletions as markers of response to therapies for high-grade serous ovarian cancer (HGSOC) patients. The model is generated by transfecting a human breast...
11:27 AM, May 15, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Other Genome-modified, antigen-specific T cells could be used to deliver therapeutic proteins. The method involves using a conventional transposon system to insert a construct that produces the therapeutic protein into a T cell line...

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