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3131 items
2:51 PM, Nov 13, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: Transgenics and knockouts miR-378-deficient mice could be used to screen therapies for muscular dystrophy. Mice with miR-378 knocked out recapitulated the low muscle weight, poor motor performance, defects in autophagy, mitochondrial abnormalities and skeletal muscle...
10:47 AM, Nov 13, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: Transgenics and knockouts miR-137-deficient mice could be used to screen therapies for schizophrenia, autism and other neuropsychiatric disorders. Mice with miR-137 knocked out in CNS and peripheral nervous system neurons recapitulated the learning and memory...
10:47 AM, Nov 13, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: Plasma markers A ratio based on counts of fragmentation sites in plasma cfDNA could help diagnose HCC. In a patient with both HCC and HBV infection and a patient with HBV infection, genomic sequencing...
10:47 AM, Nov 13, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: Cell models Gene expression profiles in neural progenitor cells derived from patients' iPS cells could be used to screen therapies for schizophrenia. The method involves generating neural progenitor cell lines from iPS cells derived from...
10:47 AM, Nov 13, 2018  |  BC Innovations | Distillery Techniques

Imaging

TECHNOLOGY: MRI A machine learning-based method of analyzing neuroimaging MRI data could help diagnose subtypes and stages of neurodegenerative diseases. For each neurodegenerative disease, the method involves: determining the number of subtypes from a training set...
10:47 AM, Nov 13, 2018  |  BC Innovations | Distillery Techniques

Assays and screens

TECHNOLOGY: Cell-free assay; diagnostic assays A nanopore-based system for quantifying metabolites in bodily fluids could be used to develop point-of-care diagnostics for multiple diseases, including stroke, Parkinson’s disease (PD) and insulin resistance. The method involves...
11:07 AM, Nov 09, 2018  |  BC Innovations | Distillery Techniques

Chemistry; drug platforms

TECHNOLOGY: Synthetic chemistry; conjugates A method for linking methionine residues to small molecules could be used to generate novel therapeutic protein-drug conjugates. The method involves two steps: adding a diazo-iodonium salt to a protein or peptide...
11:46 AM, Nov 06, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Gene therapy Streptococcus canis Cas9 could be used for CRISPR-based gene editing of a wider range of DNA targets than S. pyogenes Cas9. In a human cell line, S. canis Cas9 had higher activity at...
11:46 AM, Nov 06, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Viral vectors IL-1β and IL-6 inhibitors could help reduce immune responses to AAV vectors used for gene therapies. In peripheral blood mononuclear cell (PBMC) cultures from healthy volunteers, AAV serotype 2 (AAV2) peptide antigens increased...
11:46 AM, Nov 06, 2018  |  BC Innovations | Distillery Techniques

Assays and screens

TECHNOLOGY: Diagnostic assays Serum levels of two 10-miRNA panels could help diagnose ovarian tumors. In a cohort of 333 patients with ovarian cancers, 66 with borderline ovarian tumors, 29 with benign ovarian tumors, 859 with...

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