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9:44 AM, Sep 19, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs SNPs on PKN1, DOK2 and APOB could help predict the risk of pancreatic ductal adenocarcinoma (PDAC) in the Chinese population. In 943 PDAC patients and 3,908 healthy volunteers of Chinese descent, whole-exome screening identified...
9:44 AM, Sep 19, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Other Degradable aminoester cations could be used to deliver mRNA-based cancer vaccines. The delivery system involves complexing both an antigen-coding mRNA and an adjuvant with oligo(α-aminoester) cations that are endocytosed by any cell and degrade...
9:43 AM, Sep 19, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: Gene profiling; tissue markers Tumor levels of a nine-gene signature could help predict survival in TNBC. In 868 epithelial cells from tumor samples from six patients with primary non-metastatic TNBC, single-cell RNA sequencing, gene expression...
9:42 AM, Sep 19, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Cell therapy A method for differentiating HSPCs into megakaryocytes by overexpressing or activating one of 15 genes could help generate platelet-producing megakaryocyte colonies for thrombocytopenia. The method involves two steps: generating megakaryocyte progenitor cells by...
9:42 AM, Sep 19, 2018  |  BC Innovations | Distillery Techniques

Assays and screens; biomarkers; other

TECHNOLOGY: Bioinformatics; gene profiling; computational models Computational models based on tumor levels of lncRNAs could help predict resistance to cancer therapies. The method involves a machine learning algorithm that uses the expression levels of 2,614...
9:42 AM, Sep 19, 2018  |  BC Innovations | Distillery Techniques

Chemistry

TECHNOLOGY: Tool compounds A heterocycloalkynylbenzimide-based dual DDR1/DDR2 inhibitor could be used to probe the role of two proteins in inflammatory diseases. Chemical synthesis and in vitro activity assays of heterocycloalkynylbenzimide analogs identified a compound that...
12:29 PM, Sep 10, 2018  |  BC Innovations | Distillery Techniques

Drug platforms

TECHNOLOGY: Gene therapy Extension and chemical modification of the 5’ end of CRISPR RNAs (crRNAs) could enhance the editing efficiency and serum stability of CRISPR-Cas12a-based gene therapies. The method involves modifying crRNAs at the 5’ end...
12:28 PM, Sep 10, 2018  |  BC Innovations | Distillery Techniques

Disease models

TECHNOLOGY: 3-D models Patient-derived oligocortical spheroids could be used to study demyelinating diseases and screen therapies to treat them. The spheroids were generated by culturing human pluripotent stem cells with platelet derived growth factor AA (PDGFAA),...
12:27 PM, Sep 10, 2018  |  BC Innovations | Distillery Techniques

Assays and screens; other

TECHNOLOGY: Cellular assays; computational models An algorithm based on cytometric data from multiple studies could help identify cell populations as diagnostic or prognostic markers of disease. The algorithm involves three steps. First, it processes raw...
12:27 PM, Sep 10, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Nanoparticles Nanoparticles bound to red blood cells (RBCs) could be used to deliver drugs to the vasculature of specific organs. The method involves mixing bare nanogels with ex vivo RBCs to enable RBC-nanoparticle binding, then...

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