Having trouble accessing articles? Reset your cache.

Targeting tankyrase

Researchers from the University of Oslo and Roche's Genentech Inc. unit have developed several selective inhibitors of tankyrases TNKS and TNKS2, two druggable targets in the otherwise hard-to-hit WNT pathway.1,2 The University team's lead compound has been licensed to Odin Therapeutics A/S for colorectal cancer.

Excessive signaling by the wingless-type MMTV integration site (WNT) pathway drives cell regeneration in a range of solid tumors, but companies have struggled to find therapeutically tractable targets. The tankyrases-a pair of enzymes that normally work by modifying a range of cellular proteins with ADP-ribose-are the best-validated downstream target for inhibiting WNT signaling, according to Genentech senior scientist in the department of cancer targets Mike Costa, whose team has a project to identify new WNT pathway targets.

In 2009, researchers at Novartis AG's

Read the full 1263 word article

User Sign In

Trial Subscription

Get a two-week free trial subscription to BioCentury

SIGN UP

Article Purchase

This article may not be distributed to non-subscribers
More Info >PURCHASE