ARTICLE | Cover Story
Bringing macrocycles full circle
November 15, 2012 8:00 AM UTC
The opportunity afforded by macrocycles and constrained peptides to open up vast new therapeutic real estate is rivaled only by the challenge of puzzling out the basic science underlying these molecules.
Now, a think tank convened by SciBX has outlined an agenda for how to shed light into this black box, potentially providing a path to systematically identify macrocycle- or constrained peptide-based medicines that would combine the cell permeability and oral bioavailability of small molecules with the potency and selectivity of mAbs...