No place like exosome

University of Oxford researchers have generated targeted exosomes that can deliver RNAi payloads across the blood brain barrier, which could simplify the delivery of oligonucleotide-based therapeutics into the CNS.¹ The researchers are now refining the methods they use to load and target the exosomes.

Exosomes are vesicles secreted by cells that facilitate intercellular communication and removal of unneeded cellular components. A 2007 study from a Swedish group showed that exosomes also can shuttle RNA.²...