Combining antibodies to eliminate NHL
by combining the anti-CD20 antibody with mAbs against CD47.1 The group thinks the combination could elicit fewer side effects than Rituxan plus chemotherapy, which is standard care for the blood cancer.
Rituxan is a chimeric antibody marketed by Biogen Idec Inc. and the Genentech Inc. unit of Roche to treat non-Hodgkin's lymphoma (NHL), chronic lymphocytic leukemia (CLL), rheumatoid arthritis (RA) and multiple sclerosis (MS). In cancer, the antibody induces cell death via apoptosis and antibody-dependent cellular cytotoxicity (ADCC), which helps promote phagocytosis.2
Rituxan alone is not curative for most B cell lymphomas, and some cancers have developed resistance to the antibody, which has led to adoption of a first-line therapy combining it with chemotherapy.3
In hopes of taking chemo out of the equation, Irving