2016 study on gut integrin HIV target can't be replicated

Three preclinical studies and one clinical trial could not replicate the antiviral effects of an antibody against α4β7 to treat HIV or simian immunodeficiency virus, casting doubt on a theory that preventing CD4+ T cells from homing to the gut could control HIV infection.

Integrin α4β7 is a surface protein used by CD4+ T cells to gain entry

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