Forty Seven sees combo opportunities for Weissman's latest ‘don't eat me’ signal

Forty Seven believes the latest study from founder Irving Weissman could point to combination strategies for blocking “don’t eat me signals” on tumors, but thinks inhibitors of the CD24-SIGLEC10 interaction described in the paper will target a narrower set of phagocytes than CD47 pathway inhibitors.

In a Nature study published Wednesday, Weissman's team showed CD24 on cancer cells engages SIGLEC10 on tumor-associated macrophages (TAMs) to block tumor phagocytosis. Genetically disrupting the interaction between CD24 and SIGLEC10 or blocking it with an anti-CD24 mAb promoted phagocytic clearance of cancer cells in culture and in vivo...