Langer study describes once-monthly dosing system for tuberculosis
The scientific team behind drug delivery company Lyndra Therapeutics described a delivery device capable of releasing large payloads into the stomach over several weeks in a paper published in Science Translational Medicine on Wednesday. While the device is designed to improve compliance for long-term, frequently dosed treatment regimens, such as for tuberculosis, it does require an invasive nasogastric tube for placement and delivery.
In the paper, Robert Langer, Giovanni Traverso and colleagues described the device, dubbed a gastric release system (GRS), as a string of multiple pills along a superelastic nitinol wire with a retainer and tubing at the end. The pills are formulated in a silicon matrix and encapsulated in a polymer coating for sustained delivery...