BioCentury
ARTICLE | Preclinical News

Downshifting CARs for better mileage

December 17, 2018 10:19 PM UTC

A study from Michel Sadelain's lab at the Memorial Sloan Kettering Cancer Center suggests that CARs with only one signaling domain are less prone to exhaustion and more equipped to form memory responses than CARs with the usual three domains.

CARs are composed of an extracellular antigen binding domain connected via a transmembrane linker to an intracellular signaling domain, which typically contains three immunoreceptor tyrosine-based activation motifs (ITAMs) within the CD3ζ (CD3z; CD247) dimer chain...

BCIQ Target Profiles

CD3zeta (CD3z) (CD247)