Mayo Clinic team implicates senescent cells in neurodegenerative diseases

Clearing out senescent brain cells could prevent tau-mediated neurodegeneration and cognitive loss, although it's still too early to determine whether the approach can halt or reverse disease progression, according to a Nature letter from Mayo Clinic.

Targeting cellular senescence is increasingly viewed as a therapeutic route as evidence mounts that accumulation of the cells over time can promote cancer and age-related diseases. The permanently damaged cells have been observed in patients with neurodegenerative diseases...