ARTICLE | Preclinical News
Dual therapy could treat AD -- if it can cross into clinic
September 6, 2018 10:10 PM UTC
Researchers at Massachusetts General Hospital and colleagues found concurrently inducing neurogenesis and raising neuroprotective brain-derived neurotrophic factor (BDNF) levels could treat Alzheimer's disease, but it's not clear if -- or how -- such strategies could translate into the clinic.
A growing body of research has long pointed to BDNF's neuroprotective effects, including a 2009 Nature Medicine article showing higher BDNF consistently protected against synapse loss, neuronal death and atrophy in six AD mouse, rat and monkey models (see "New Home for BDNF")...
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