BioCentury
ARTICLE | Preclinical News

New approach could identify Ras-blocking small molecules

August 10, 2018 10:49 PM UTC

With an eye on historically undruggable cancer target Ras, a University of Oxford team and colleagues devised a way to find small molecules that have the same qualities as Ras inhibitors too large to access the intracellular targets.

Ras proteins are particularly attractive as an intracellular target for cancer: nearly a third of all cancers have mutated K-Ras (KRAS), neuroblastoma Ras viral (v-Ras) oncogene (NRAS) and v-Ha-ras Harvey rat sarcoma viral oncogene homolog (HRAS)...