BioCentury
ARTICLE | Preclinical News

New uses for marketed drugs in tough-to-treat indications

July 6, 2018 7:50 PM UTC

Two studies in Science Translational Medicine suggest three generics could be repurposed for difficult to treat indications.

A paper from University of Edinburgh researchers showed that endothelial cell-targeted drugs simvastatin and perindopril could help treat patients with cerebral small vessel disease, a disorder characterized by white matter damage and a leaky blood-brain barrier. According to the paper, small vessel disease is one of the most common causes of dementia, with one-third of people over the age of 80 showing signs of it. There are currently no established therapies to treat the disease...