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ARTICLE | Preclinical News

Striatal dopamine signaling regulates glucose metabolism

May 24, 2018 10:33 PM UTC

Researchers at Academic Medical Center (AMC) found that dopamine signaling is a key regulator of systemic glucose metabolism, which could guide exploration of new targets or interventions to increase insulin sensitivity in patients with chronic diseases such as Type II diabetes. The findings appeared in Science Translational Medicine.

Research has pointed toward a potential relationship between striatal dopamine activity and glucose regulation. In this study, the AMC group found direct evidence of this interplay in humans and mice, beginning with a case study in a diabetic patient whose total daily insulin dose decreased after he underwent deep brain stimulation as a striatal dopamine-releasing therapy to treat his severe obsessive-compulsive disorder (OCD)...

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