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ARTICLE | Preclinical News

Study challenges FCGR2A as latent HIV marker

April 18, 2018 9:32 PM UTC

A paper in Science Translational Medicine suggests the T cell surface receptor Fc gamma receptor IIa (FCGR2A; CD32A) is a marker of T cells that are actively infected with HIV, rather than those with latent viral infection, refuting a 2017 Nature study that proposed FCGR2A could be used to identify and target latent HIV reservoirs.

While antiretroviral therapy (ART) can control HIV infection by blocking viral replication, the virus hides out in immune cells by inserting itself into the cells' chromosome, creating latent viral reservoirs that rebound if therapy is stopped...