Researchers identify coding, non-coding driver mutations in MM

Scientists from the Institute of Cancer Research (London, U.K.) identified coding and non-coding driver mutations involved in newly diagnosed multiple myeloma, suggesting the genes could be targeted to treat the disease. The research was published in Leukemia.

According to the authors, identifying driver mutations in MM has focused on protein-coding components using whole-exome sequencing, but whole-genome sequencing can be used to evaluate genomic non-coding regions -- such as cis-regulatory elements and promoters of gene expression -- for mutations...