Pig model of Huntington's disease mimics human disease

In a paper published in Cell, an international team of researchers developed a knock-in pig model of Huntington's disease that recapitulates neurological and respiratory symptoms of the disease in humans.

Huntington's disease is caused by protein misfolding of mutant Huntingtin (HTT) due to large numbers of CAG trinucleotide repeats in the gene. Longer repeats correlate with earlier disease onset and increased disease severity...