Study counters CRISPR-Cas9 variant concerns

A study by Wellcome Sanger Institute researchers showed CRISPR-Cas9 (CRISPR-associated protein 9) produced no unexpected off-target edits in mice, countering a 2017 report of high off-target activity and confirming doubts about that study's results from CRISPR experts. The new study, not yet peer-reviewed, was published on the preprint server bioRxiv.

In a letter published in Nature Methods last year, researchers from Stanford University, Columbia University and the University of Iowa said the CRISPR-Cas9 gene editing technique led to unexpected off-target mutations in mice, causing shares of gene editing companies to sink (see BioCentury Innovations, June 1, 2017)...