BioCentury
ARTICLE | Preclinical News

Cholesterol efflux in phagocytes may promote remyelination

January 4, 2018 11:32 PM UTC

A report published in Science suggests stimulating cholesterol efflux in phagocytes may promote remyelination in aged individuals, offering a potential regenerative strategy for patients who have had multiple sclerosis or other demyelinating disorders for long periods of time.

The capacity to remyelinate damaged axons decreases with age, but the mechanism underlying the reduced regenerative potential is unknown...