4:21 PM
Nov 08, 2017
 |  BC Extra  |  Preclinical News

LAMB3 gene therapy successfully treats epidermolysis bullosa

In a paper published in Nature, researchers from Ruhr University Bochum and colleagues described the successful regeneration and engraftment of almost the entire epidermis of a patient with junctional epidermolysis bullosa (JEB) using laminin beta 3 (LAMB3) gene replacement in epidermal progenitor cells called holoclones.

JEB is caused by mutations in genes encoding the basement membrane component laminin-332, and the 7-year-old patient had a...

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