Paper identifies target for TBI-related cognitive defects

In a paper published in Proceedings of the National Academy of Sciences, researchers at the University of California San Francisco suggest inhibiting the integrated stress response (ISR) pathway could help treat cognitive deficits due to traumatic brain injury.

The integrated stress response is an intracellular pathway that regulates protein translation via phosphorylation of eukaryotic translation initiation factor 2 (eIF2) subunit alpha (eIF-2alpha; EIF2S1). Phosphorylation of eIF-2alpha has been shown to affect long-term memory formation...