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Tilos takeout sees Merck tapping TGFβ to solve checkpoint resistance

In its ongoing quest to find combinations for Keytruda pembrolizumab, Merck is acquiring two-year-old Tilos for its ability to modulate TGFβ, a target that’s been gaining interest on the back of clinical data in immuno-oncology, according to Tilos CEO Barbara Fox.

Shareholders of Tilos Therapeutics Inc. (Lexington, Mass.) could receive up to

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