BioCentury
ARTICLE | Clinical News

resTORbio forging ahead with anti-infective after Phase IIb readout

July 25, 2018 8:57 PM UTC

Data from Part 2 of a Phase IIb trial evaluating RTB101 from resTORbio Inc. (NASDAQ:TORC) to prevent respiratory tract infections showed that all three dose regimens of the candidate missed the study's primary endpoint vs. placebo. However, based on a prespecified pooled analysis of the trial's Parts 1 and 2 in which one dose did significantly improve the primary endpoint, resTORbio plans to start Phase III trials next year of that dose.

The two-part Phase IIb trial enrolled a total of 652 elderly patients at increased risk of morbidity and mortality associated with respiratory tract infections. Part 1 evaluated once-daily 5 and 10 mg doses of RTB101 vs. placebo; patients in Part 2 received placebo, 10 mg RTB101 once or twice daily, or the 10 mg dose once daily plus Afinitor everolimus...