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ARTICLE | Clinical News

Nektar reports updated response data for immuno-oncology combo

May 16, 2018 9:02 PM UTC

Nektar Therapeutics (NASDAQ:NKTR) reported response data from 60 evaluable patients with solid tumors who were naïve to immunotherapy in the Phase Ib/II PIVOT-02 trial evaluating the company's NKTR-214 plus anti-PD-1 mAb Opdivo nivolumab. The data were released in an abstract ahead of the American Society of Clinical Oncology meeting in Chicago.

NKTR-214 is an immunostimulatory cytokine engineered to selectively activate IL-2 receptor beta chain (CD122; IL2RB) receptors on cytotoxic T cells, resulting in increased PD-1 expression on T cells and NK cells in the tumor microenvironment...