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8:13 PM, Aug 16, 2018  |  BC Week In Review | Clinical News  |  Clinical Results

Amgen's Repatha lowers LDL-C in Phase III for dyslipidemia in Type II diabetics

Amgen Inc. (NASDAQ:AMGN) reported in June that Repatha evolocumab met the co-primary endpoints in the Phase III BANTING trial to treat hypercholesterolemia or mixed dyslipidemia in Type II diabetics taking the maximum tolerated dose of...
8:12 PM, Aug 16, 2018  |  BC Week In Review | Clinical News  |  Clinical Results

Genentech reports Phase II data for sustained delivery eye implant of ranibizumab

The Genentech Inc. unit of Roche (SIX:ROG; OTCQX:RHHBY) said the majority of patients who received Port Delivery System (PDS) administration of ranibizumab were able to go six months or longer between implantation and the first...
6:46 PM, Aug 16, 2018  |  BC Innovations | Targets & Mechanisms

Unsaturated remyelination

Enzymes downstream in cholesterol biosynthesis could provide new ways to stimulate remyelination that avoid the baggage of previously identified multiple sclerosis targets, according to a group at Case Western. The university is spinning out Convelo...
5:52 PM, Aug 16, 2018  |  BC Innovations | Targets & Mechanisms

RNA party

A study in Cell uncovered a brain regulatory network involving a circular RNA, a long non-coding RNA and two microRNAs, and could provide some much needed insights in a field where finding links to disease...
4:24 PM, Aug 16, 2018  |  BC Extra | Politics & Policy

Innovative drugs reformer Bi out amid China vaccines scandal

Thursday’s resignation of Jingquan Bi, party secretary of the State Administration of Market Supervision, means that China has lost a champion of innovative biopharma products; however, it remains to be seen whether his departure will...
3:55 PM, Aug 16, 2018  |  BC Innovations | Distillery Therapeutics

Dermatology; pulmonary

INDICATION: Dermatology; pulmonary fibrosis Cell culture and mouse studies suggest inhibiting SHP-2 could help treat dermal and pulmonary fibrosis. In primary human dermal fibroblasts stimulated with the fibrosis mediator transforming growth factor β 1(TGFB1), levels of...
3:54 PM, Aug 16, 2018  |  BC Innovations | Distillery Techniques

Biomarkers; Other

TECHNOLOGY: Gene profiling; computational models An algorithm-based method for predicting the consequences of gene mutations on protein function could help identify mutations as risk markers for disease. The method involves using a data set, comprising...
3:54 PM, Aug 16, 2018  |  BC Innovations | Distillery Techniques

Assays and screens; drug properties

TECHNOLOGY: Cellular assays; toxicology Human kidney cells cultured on decellularized rat kidney extracellular matrix (ECM) scaffolds could be used to screen compounds for nephrotoxicity. The method involved treating rat kidney tissue samples with detergent and DNAse...
3:32 PM, Aug 16, 2018  |  BC Extra | Company News

Management tracks: Achillion, Navidea

Rare disease company Achillion Pharmaceuticals Inc. (NASDAQ:ACHN) hired Anthony Gibney as EVP and CBO. He was managing director and co-head of the biotechnology investment banking team at Leerink Partners. Immunotherapy company Navidea Biopharmaceuticals Inc. (NYSE-A:NAVB; Tel...
2:59 PM, Aug 16, 2018  |  BC Extra | Politics & Policy

Trump calls for federal lawsuit against opioid companies

Upon President Donald Trump's request, Attorney General Jeff Sessions agreed during a cabinet meeting Thursday to sue U.S. drug manufacturers for aiding the opioid crisis. While several states have already filed suit against companies such...

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