ARTICLE | Clinical News
Pharmacyclics preclinical data
February 18, 2008 8:00 AM UTC
In vitro, the selectivity of PCI-34051 for histone deacetylase 8 (HDAC8) was 200-1,000 times greater than other HDAC enzymes tested. The HDAC8 inhibitor also induced caspase-dependent apoptosis in c...