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ARTICLE | Emerging Company Profile

PAQ: small molecules for autophagy-dependent degradation

Emerging Company Profile: PAQ is creating small molecules that promote autophagy-dependent degradation of proteins and non-proteins

July 22, 2021 8:34 PM UTC

With a July 15th $30 million series A round led by Sherpa Partners, PAQ joins a growing number of biotechs developing autophagy-dependent degraders that could push targeted degradation beyond protein substrates. 

PAQ Therapeutics Inc. is designing autophagosome-tethering compounds (ATTECs) in which one part of the molecule binds a component of the autophagy pathway and another part binds to a disease-causing substrate...