Scenic: targeting genetic modifiers to suppress disease drivers

Scenic Biotech is building a compendium of genetic data to identify rare, naturally occurring genetic modifiers that suppress disease pathology despite the presence of disease-causing mutations.

Many rare diseases are driven by an underlying genetic mutation. But across nearly all of these patient populations, there is a small subset of patients that have no disease traits because they have a genetic modifier — a second rare genetic mutation that prevents the phenotypic expression of that disease. ...