Macrophage therapies to watch at AACR

Macrophage cell therapies may make headlines this weekend as the first CAR macrophage data in an immunocompetent animal model read out at AACR, but the conference will also showcase a spate of other strategies designed to harness antitumor activity of the innate immune cells. 

As the understanding of the immune system’s role in cancer has evolved past effector T cells, macrophages have emerged as one of the newest sources of immuno-oncology targets and therapies — a trend BioCentury has been tracking at the American Association for Cancer Research (AACR) meeting since 2019. ...