Moderna, NIH pick Phase III COVID-19 vaccine dose, show off highest neutralizing titers to date

Moderna revealed on Tuesday that prime-boost administration of low and medium doses of its COVID-19 vaccine induced the highest neutralization titers reported in humans to date, as well as a T cell response. The company plans to move forward with the medium dose in its imminent Phase III trial.

Whether high neutralizing antibody (NAb) titers are enough to prevent SARS-CoV-2 infection or reduce severity in humans remains an open question...