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Precise base editing of mitochondrial DNA

A new RNA-free tool to edit the mitochondrial genome

David Liu and colleagues at the Broad Institute and University of Washington have achieved single-base editing of mitochondrial DNA for the first time, overcoming a limitation of CRISPR-based technologies and opening up new avenues for treating mitochondrial diseases.

Liu, a CRISPR veteran and base editing pioneer, is a co-founder of CRISPR and base editing

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