Targeting the super elongation complex for diffuse midline glioma

INDICATION: Brain cancer

Inhibiting AFF4 and CDK9, components of the transcription-regulating super elongation complex, could treat diffuse midline glioma. In human diffuse midline glioma cell lines, shRNAs targeting AFF4 or CDK9 or CDK9 inhibitors alvocidib, atuveciclib or AZD4573 reduced proliferation. In a xenograft mouse model, atuveciclib and AZD4573 extended overall survival and decreased tumor growth, peritumoral edema and invasion of surrounding anatomic structures...