DNA-based HGF/SF mimetic for hepatitis

INDICATION: Hepatitis

An oligonucleotide-based mimetic of HGF/SF, a growth factor that can stimulate liver regeneration, could treat hepatitis. The HGS/SF mimetic comprises a dimer of two 50-nucleotide single-stranded DNA molecules. In mice with fulminant hepatitis, the HGF/SF mimetic reduced plasma levels of three liver injury markers: aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and alanine aminotransferase (ALT)...