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DATA GRAPHICS | Targets & Mechanisms

Daily Chart: primate data hint full-length SARS-CoV-2 spike more potent vaccine antigen than spike peptides

May 21, 2020 8:14 PM UTC

Full-length spike protein may make a better DNA vaccine against SARS-CoV-2 than smaller spike peptides, including the popular receptor binding domain, according to a Science paper published Thursday.

Led by Harvard’s Beth Israel Deaconess Medical Center (BIDMC), the research team compared the ability of five spike variants to induce neutralizing antibodies in non-human primates and protect the animals from viral challenge. ...