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Coronavirus protease structure guides optimization of inhibitor

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March 21, 2020 12:29 AM UTC
Updated on Mar 25, 2020 at 10:45 PM UTC

By solving the crystal structure of a SARS-CoV-2 protease, a University of Luebeck team was able to optimize a previously developed inhibitor for greater potency against the virus.

In a paper published in Science on Friday, the Luebeck group described the X-ray crystal structure of 3CLpro, which is key for the virus' replication, as well as the antiviral activity of an inhibitor tailored to the protease's structure. ...

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University of Luebeck