OncoOne: targeting oxidized MIF for solid tumors

A trio of Shire veterans launched OncoOne on Wednesday with a €13 million series A round and a batch of biologics against oxidized MIF, a highly selective tumor antigen that was abandoned by the pharma when it shifted away from oncology R&D.

While the unmodified form of MIF, a well-known cytokine, is distributed throughout healthy tissues, the oxidized form is highly tumor cell-specific...